ea0036P60 | (1) | BSPED2014
Novoselova Tatiana
, Larder Rachel
, Rimmington Debra
, Lelliott Chris
, Wynn Elizabeth
, O'Rahilly Stephen
, Clark Adrian
, Logan Darren
, Coll Anthony
, Chan Li
Recently, rare loss-of-function mutations of melanocortin-2-receptor accessory protein 2 (MRAP2) have been associated with severe, early-onset obesity in humans. In addition, whole body deletion and targeted brain specific deletion of the Mrap2 gene resulted in severe obesity in mice. In vitro data have shown Mrap2 interaction with the melanocortin-4-receptor (MC4R) affecting receptor signalling as a consequence. However, the mechanism by which Mrap2...